Note in Science page
Created Jun 30 08, Updated Aug 04 08 17:48
Granulocytes transfusion against cancer go to comments

Simple cancer cure soon to be tested in humans

Scientists have shown that transfusion of white blood cells from cancer-resistant mice can completely destroy tumours in mice, curing 100 percent of lab mice afflicted with advanced cancer! (See note below), and are about to embark on a human trial to test whether this technique also works in humans.


Granulocytes (among Platelets) © www.sciencemuseum.org.uk

Scientist have since identified similar cancer-killing activity in the white blood cells of some healthy humans (bbc news link). The anti-tumor activity seems to be primarily confered by granulocyte immune cells

In a small study of human volunteers, it was found that granulocytes cancer-killing activity was highest in people under age 50. They also found that this activity can be lowered by factors such as winter or emotional stress. Therefore the key to the success for the new therapy is to transfuse sufficient granulocytes from the best donors while their cancer-killing activities are at their peak level.

In mice, we’ve been able to eradicate even highly aggressive forms of malignancy with extremely large tumors … Hopefully, we will see the same results in humans. Our laboratory studies indicate that this cancer-fighting ability is even stronger in healthy humans (Zheng Cui).

Scientists at Wake Forest University Baptist Medical Center are about to embark on a human trial, and are currently recruiting 500 local potential donors who are 50 years old or younger and in good health to have their blood tested. Of those, 100 volunteers with high cancer-killing activity will be asked to donate white blood cells for the study. Cell recipients will include 22 cancer patients who have solid tumors that either didn’t respond originally, or no longer respond, to conventional therapies.

sciencentral link
sciencedaily link

Note: what about host rejection of foreign cells (graft-versus-host) ? It seems granulocytes don’t induce such rejection, but other immune cells that might could be injected by mistake during the transfusion (so the cells have to be extremely well sorted?)!


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