Note in Science page
Created Nov 02 11, Updated Jan 05 12 12:30
N-acetylcysteine might treat Progeria go to comments

Researchers found, in cultured cells, that N-acetylcysteine, a widely-used “drug” / food complement – “soaking up” reactive oxygen (among other things) – could prevent (some of?) the molecular damages occurring in Hutchinson Gilford progeria – a condition where children age up to eight times too quickly.
It hasn’t yet been given to children with the illness… A real full randomised clinical trial of the drug is not possible as the condition is so rare (78 cases worldwide!), but it could/will be tried.


(metal rust © youthedesigner.com)

Our findings suggest that un-repaired Reactive oxygen species – induced DNA double-strand breaks [= DNA damages] contribute significantly to the [restrictive dermopathy] RD and [Hutchinson Gilford progeria syndrome] HGPS phenotypes and that inclusion of [N-acetylcysteine] NAC in a combinatorial therapy might prove beneficial to HGPS patients.

BBC News article

original publication:
The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine, Human Molecular Genetics (2011) 20 (20): 3997-4004. doi: 10.1093/hmg/ddr327

p.s. Jan 2012

Stem cell-like progenitor cells (derived from the muscle of young healthy mice) injection doubles progeric mice lifespan: science daily article


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