Note in Science page
Created Aug 25 15, Updated Aug 26 15 09:37
Adhesion proteins and miRNA signals: a new strategy for cancer therapy? go to comments

Researchers have shown that some miRNA (especially miR-30b) act as a cellular division brake and are under the control of the PLEKHA7 complex from cellular junctions: linking cell-to-cell adhesion and miRNA biology and uncovering potential new strategies for cancer therapy.


cell jonctions © wikimedia.org

The basolateral (tight junctions ?) junctional complex promotes growth and expression of transformation-related (cancer) markers. It is the disruption of the PLEKHA7-associated apical ZA (Zonula Adherens) “junctional” complex that results in induction of growth-related signalling (from basolateral complex). PLEKHA7 – the brake – is either mislocalized or lost in the tumour tissues.
PLEKHA7 suppresses expression of SNAI1, MYC and CCND1 through miRNAs. PLEKHA7 regulates processing of pri-miR-30b at the junctions.

By administering the affected miRNAs in cancer cells to restore their normal levels, we should be able to re-establish the brakes and restore normal cell function [= “cancer cell’s off switch”]. Initial experiments in some aggressive types of cancer are indeed very promising.
(seen in medicalnewstoday article not in cell biology publication !?)

Nature Cell Biology paper
Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity Nature Cell Biology (2015) doi:10.1038/ncb3227


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