Note in Science page
Created Feb 05 16, Updated Feb 05 16 11:27
A paradigm shift for cancer? go to comments

Researchers have proven that (certain) cancer develops only when a cell in the tissue reverts to a more primitive, embryonic state and starts dividing.


A zebra fish © wikimedia.org

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

They followed GFP tagged Crestin expression in live zebrafish: positive cells (in adults) became tumors 100 percent of the time!

Thus, in addition to the typical fixed genetic alterations in oncogenes and tumor supressors that are required for cancer development, THE REEMERGENCE OF PROGENITOR IDENTITY MAY BE AN ADDITIONAL RATE-LIMITING STEP IN THE FORMATION OF MELANOMA. Preventing NCP reemergence in a field of cancer-prone melanocytes may thus prove therapeutically useful.

I’ve seen elsewhere that they believe this model may apply to most if not all cancers! (their model:) Cancer develops only when a cell in the tissue reverts to a more primitive, embryonic state and starts dividing.

If one could block this “embryonic” program, this might represent a single / SILVER BULLET weapon against most cancer!?

(Isn’t that cancer = reversion to embryonic state, very old thinking/knowledge?)

A cancer’s surprise origins caught in action (Science Daily article)


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